Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer

Epithelial to mesenchymal transition (EMT) in colorectal cancer (CRC) has been attributed to activation of AKT and Notch1 signaling pathways. As EMT corresponds to increased aggressiveness of CRC, approaches that prevent metastasis by targeting AKT/Notch1 pathways are at the forefront of current res...

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Detalles Bibliográficos
Autores principales: Pal, Deeksha, Tyagi, Ashish, Chandrasekaran, Balaji, Alattasi, Houda, Ankem, Murali K., Sharma, Arun K., Damodaran, Chendil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056562/
https://www.ncbi.nlm.nih.gov/pubmed/30038258
http://dx.doi.org/10.1038/s41419-018-0810-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056562/
https://www.ncbi.nlm.nih.gov/pubmed/30038258
http://dx.doi.org/10.1038/s41419-018-0810-8

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