Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex

The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator...

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Autores principales: Miao, Nan, Bian, Shan, Lee, Trevor, Mubarak, Taufif, Huang, Shiying, Wen, Zhihong, Hussain, Ghulam, Sun, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056652/
https://www.ncbi.nlm.nih.gov/pubmed/30065628
http://dx.doi.org/10.3389/fnmol.2018.00247
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author Miao, Nan
Bian, Shan
Lee, Trevor
Mubarak, Taufif
Huang, Shiying
Wen, Zhihong
Hussain, Ghulam
Sun, Tao
author_facet Miao, Nan
Bian, Shan
Lee, Trevor
Mubarak, Taufif
Huang, Shiying
Wen, Zhihong
Hussain, Ghulam
Sun, Tao
author_sort Miao, Nan
collection PubMed
description The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity in vitro. Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex.
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spelling pubmed-60566522018-07-31 Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex Miao, Nan Bian, Shan Lee, Trevor Mubarak, Taufif Huang, Shiying Wen, Zhihong Hussain, Ghulam Sun, Tao Front Mol Neurosci Neuroscience The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear. Here, we show that Wnt7a and secreted frizzled-related protein 1 (Sfrp1), a soluble modulator of Wnts, are co-expressed in mouse embryonic cortical neural progenitors (NPs). Knockout of Wnt7a in mice causes microcephaly due to reduced NP population and neurogenesis, and Sfrp1 has an opposing effect compared to Wnt7a. Similar to Dkk1, Sfrp1 decreases the Wnt1 and Wnt7a activity in vitro. Our results suggest that Wnt7a and Sfrp1 play opposite roles to ensure proper NP progeny in the developing cortex. Frontiers Media S.A. 2018-07-17 /pmc/articles/PMC6056652/ /pubmed/30065628 http://dx.doi.org/10.3389/fnmol.2018.00247 Text en Copyright © 2018 Miao, Bian, Lee, Mubarak, Huang, Wen, Hussain and Sun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Miao, Nan
Bian, Shan
Lee, Trevor
Mubarak, Taufif
Huang, Shiying
Wen, Zhihong
Hussain, Ghulam
Sun, Tao
Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
title Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
title_full Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
title_fullStr Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
title_full_unstemmed Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
title_short Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex
title_sort opposite roles of wnt7a and sfrp1 in modulating proper development of neural progenitors in the mouse cerebral cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056652/
https://www.ncbi.nlm.nih.gov/pubmed/30065628
http://dx.doi.org/10.3389/fnmol.2018.00247
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