Application of nSMOL coupled with LC‐MS bioanalysis for monitoring the Fc‐fusion biopharmaceuticals Etanercept and Abatacept in human serum

The principle of nano‐surface and molecular‐orientation limited (nSMOL) proteolysis has a unique characteristic Fab‐selective proteolysis for antibody bioanalysis that is independent of a variety of monoclonal antibodies by the binding antibody Fc via Protein A/G in a pore with 100 nm diameter and m...

Descripción completa

Detalles Bibliográficos
Autores principales: Iwamoto, Noriko, Yokoyama, Kotoko, Takanashi, Megumi, Yonezawa, Atsushi, Matsubara, Kazuo, Shimada, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056752/
https://www.ncbi.nlm.nih.gov/pubmed/30062014
http://dx.doi.org/10.1002/prp2.422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056752/
https://www.ncbi.nlm.nih.gov/pubmed/30062014
http://dx.doi.org/10.1002/prp2.422

Ejemplares similares