Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy

PURPOSE: Everolimus only inhibits mammalian target of rapamycin complex 1 (mTORC1), whereas Ku0063794 inhibits both mTORC1 and mTORC2. Although they have similar anticancer effects, their combination has a synergistic effect against hepatocellular carcinoma (HCC) cells. We aimed to determine the mec...

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Detalles Bibliográficos
Autores principales: Lee, Sang Chul, Kim, Kee-Hwan, Kim, Ok-Hee, Lee, Sang Kuon, Hong, Ha-Eun, Choi, Byung Jo, Jeong, Wonjun, Kim, Say-June
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056969/
https://www.ncbi.nlm.nih.gov/pubmed/29121714
http://dx.doi.org/10.4143/crt.2017.085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056969/
https://www.ncbi.nlm.nih.gov/pubmed/29121714
http://dx.doi.org/10.4143/crt.2017.085

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