The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

BACKGROUND: The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. RESULTS: Rats were pretreated with varying i.v. doses of NicA2, followed by i.v. administration of nicotine at 0.03 mg/kg. NicA2 had a rap...

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Detalles Bibliográficos
Autores principales: Pentel, Paul R., Raleigh, Michael D., LeSage, Mark G., Thisted, Thomas, Horrigan, Stephen, Biesova, Zuzana, Kalnik, Matthew W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056991/
https://www.ncbi.nlm.nih.gov/pubmed/30041697
http://dx.doi.org/10.1186/s12896-018-0457-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056991/
https://www.ncbi.nlm.nih.gov/pubmed/30041697
http://dx.doi.org/10.1186/s12896-018-0457-7

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