Effect of TP53 contact and conformational mutations on cell survival and erythropoiesis of human hematopoietic stem cells in a long term culture model

TP53 deficiencies characterize myeloid malignancies with a dismal prognosis. To unravel the pathomechanism of TP53 mutations in the development of myeloid malignancies, we analyzed the functional properties of TP53 conformational and contact mutations and TP53 loss in human CD34+ cells. We show for...

Descripción completa

Detalles Bibliográficos
Autores principales: Salari, Azam, Thomay, Kathrin, Lentes, Jana, Ebersold, Juliane, Hagedorn, Maike, Skawran, Britta, Davenport, Claudia, Schambach, Axel, Schlegelberger, Brigitte, Göhring, Gudrun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057451/
https://www.ncbi.nlm.nih.gov/pubmed/30042819
http://dx.doi.org/10.18632/oncotarget.25581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057451/
https://www.ncbi.nlm.nih.gov/pubmed/30042819
http://dx.doi.org/10.18632/oncotarget.25581

Ejemplares similares