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Exploratory re-encoding of yellow fever virus genome: new insights for the design of live-attenuated viruses

Virus attenuation by genome re-encoding is a pioneering approach for generating effective live-attenuated vaccine candidates. Its core principle is to introduce a large number of synonymous substitutions into the viral genome to produce stable attenuation of the targeted virus. Introduction of large...

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Detalles Bibliográficos
Autores principales: Klitting, R, Riziki, T, Moureau, G, Piorkowski, G, Gould, E A, de Lamballerie, X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057501/
https://www.ncbi.nlm.nih.gov/pubmed/30057792
http://dx.doi.org/10.1093/ve/vey021