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Exploratory re-encoding of yellow fever virus genome: new insights for the design of live-attenuated viruses
Virus attenuation by genome re-encoding is a pioneering approach for generating effective live-attenuated vaccine candidates. Its core principle is to introduce a large number of synonymous substitutions into the viral genome to produce stable attenuation of the targeted virus. Introduction of large...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057501/ https://www.ncbi.nlm.nih.gov/pubmed/30057792 http://dx.doi.org/10.1093/ve/vey021 |