Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits

Recent investigations of Nogo-A, a well characterized protein inhibitor of neurite outgrowth in the brain, have revealed additional functions including a role in neuropsychiatric disorders such as schizophrenia. Here we examined Nogo-A functions in mouse CA3 hippocampal circuitry. Patch clamp record...

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Detalles Bibliográficos
Autores principales: Berry, Stewart, Weinmann, Oliver, Fritz, Ann-Kristina, Rust, Ruslan, Wolfer, David, Schwab, Martin E., Gerber, Urs, Ster, Jeanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057643/
https://www.ncbi.nlm.nih.gov/pubmed/30040841
http://dx.doi.org/10.1371/journal.pone.0200896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057643/
https://www.ncbi.nlm.nih.gov/pubmed/30040841
http://dx.doi.org/10.1371/journal.pone.0200896

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