No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice

CRISPR-Cas9 technologies have transformed genome-editing of experimental organisms and have immense therapeutic potential. Despite significant advances in our understanding of the CRISPR-Cas9 system, concerns remain over the potential for off-target effects. Recent studies have addressed these conce...

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Detalles Bibliográficos
Autores principales: Iyer, Vivek, Boroviak, Katharina, Thomas, Mark, Doe, Brendan, Riva, Laura, Ryder, Edward, Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057650/
https://www.ncbi.nlm.nih.gov/pubmed/29985941
http://dx.doi.org/10.1371/journal.pgen.1007503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057650/
https://www.ncbi.nlm.nih.gov/pubmed/29985941
http://dx.doi.org/10.1371/journal.pgen.1007503

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