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No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
CRISPR-Cas9 technologies have transformed genome-editing of experimental organisms and have immense therapeutic potential. Despite significant advances in our understanding of the CRISPR-Cas9 system, concerns remain over the potential for off-target effects. Recent studies have addressed these conce...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057650/ https://www.ncbi.nlm.nih.gov/pubmed/29985941 http://dx.doi.org/10.1371/journal.pgen.1007503 |