Abp1 promotes Arp2/3 complex-dependent actin nucleation and stabilizes branch junctions by antagonizing GMF

Formation and turnover of branched actin networks underlies cell migration and other essential force-driven processes. Type I nucleation-promoting factors (NPFs) such as WASP recruit actin monomers to Arp2/3 complex to stimulate nucleation. In contrast, mechanisms of type II NPFs such as Abp1 (also...

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Detalles Bibliográficos
Autores principales: Guo, Siyang, Sokolova, Olga S., Chung, Johnson, Padrick, Shae, Gelles, Jeff, Goode, Bruce L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057921/
https://www.ncbi.nlm.nih.gov/pubmed/30042427
http://dx.doi.org/10.1038/s41467-018-05260-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057921/
https://www.ncbi.nlm.nih.gov/pubmed/30042427
http://dx.doi.org/10.1038/s41467-018-05260-y

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