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Structural Lipids Enable the Formation of Functional Oligomers of the Eukaryotic Purine Symporter UapA
The role of membrane lipids in modulating eukaryotic transporter assembly and function remains unclear. We investigated the effect of membrane lipids in the structure and transport activity of the purine transporter UapA from Aspergillus nidulans. We found that UapA exists mainly as a dimer and that...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058078/ https://www.ncbi.nlm.nih.gov/pubmed/29681524 http://dx.doi.org/10.1016/j.chembiol.2018.03.011 |