Underestimation of N‐glycoPEGylated factor IX one‐stage clotting activity owing to contact activator‐impaired activation

ESSENTIALS: Nonacog beta pegol (N9‐GP) activity can be underestimated in clot method using diverse reagents. Mimicking clotting phase with representative reagents reveals impaired FIX and N9‐GP activation. Polyethylene glycol conjugation amplifies contact activator‐induced decrease in FIX activation...

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Detalles Bibliográficos
Autores principales: Persson, Egon, La Cour Christoffersen, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles: Haemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058268/
https://www.ncbi.nlm.nih.gov/pubmed/30046695
http://dx.doi.org/10.1002/rth2.12046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058268/
https://www.ncbi.nlm.nih.gov/pubmed/30046695
http://dx.doi.org/10.1002/rth2.12046

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