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Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data
BACKGROUND: Long non-coding RNAs (lncRNAs) are typically expressed at low levels and are inherently highly variable. This is a fundamental challenge for differential expression (DE) analysis. In this study, the performance of 25 pipelines for testing DE in RNA-seq data is comprehensively evaluated,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058388/ https://www.ncbi.nlm.nih.gov/pubmed/30041657 http://dx.doi.org/10.1186/s13059-018-1466-5 |