Apremilast Ameliorates Experimental Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of CD4(+)Foxp3(+) Regulatory T Cells Differentiation

Apremilast is a novel phosphodiesterase 4 (PDE4) inhibitor suppressing immune and inflammatory responses. We assessed the anti-inflammatory effects of Apremilast in type II collagen (CII)-induced arthritis (CIA) mouse model. To determine whether Apremilast can ameliorate arthritis onset in this mode...

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Detalles Bibliográficos
Autores principales: Chen, Weiqian, Wang, Julie, Xu, Zhenjian, Huang, Feng, Qian, Wenbin, Ma, Jilin, Wee, Hwa bok, Lewis, Gregory S., June, Rayford R., Schafer, Peter H., Lin, Jin, Zheng, Song Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058600/
https://www.ncbi.nlm.nih.gov/pubmed/30072998
http://dx.doi.org/10.3389/fimmu.2018.01662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058600/
https://www.ncbi.nlm.nih.gov/pubmed/30072998
http://dx.doi.org/10.3389/fimmu.2018.01662

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