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Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine
Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics and metabolism may be influenced by microorganisms. If gut microbes are involved in the metabolism of nifedipine, plateau hypoxia may regulate the bioavailability and the therapeutic effect of nifedipine by alte...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058681/ https://www.ncbi.nlm.nih.gov/pubmed/29790376 http://dx.doi.org/10.1080/10717544.2018.1469687 |