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Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug
Gabapentin (GBP), an antiepileptic and anti-neuropathic agent, suffers from short half-life (5–7 h), has narrow absorption window, and is absorbed via carrier-mediated mechanism resulting in frequent dosing, poor compliance, and poor bioavailability (<60%). Moreover, GBP is a freely water-soluble...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058684/ https://www.ncbi.nlm.nih.gov/pubmed/29792353 http://dx.doi.org/10.1080/10717544.2018.1474969 |