Cargando…

Characterization of TRKA signaling in acute myeloid leukemia

Tropomyosin-related kinase A (TRKA) translocations have oncogenic potential and have been found in rare cases of solid tumors. Accumulating evidence indicates that TRKA and its ligand, nerve growth factor (NGF), may play a role in normal hematopoiesis and may be deregulated in leukemogenesis. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herbrich, Shelley M., Kannan, Sankaranarayanan, Nolo, Riitta M., Hornbaker, Marisa, Chandra, Joya, Zweidler-McKay, Patrick A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059018/ https://www.ncbi.nlm.nih.gov/pubmed/30046390 http://dx.doi.org/10.18632/oncotarget.25723

Ejemplares similares

Targeting P-selectin blocks neuroblastoma growth
por: Nolo, Riitta, et al.
Publicado: (2017)

Regulation of NOTCH Signaling by Reciprocal Inhibition of HES1 and Deltex 1 and its Role in Osteosarcoma Invasiveness
por: Zhang, Pingyu, et al.
Publicado: (2010)

Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy
por: Kannan, Sankaranarayan, et al.
Publicado: (2022)

Notch activation inhibits AML growth and survival: a potential therapeutic approach
por: Kannan, Sankaranarayanan, et al.
Publicado: (2013)

2180: hnRNP K overexpression drives acute myeloid leukemia emergence and progression
por: Hornbaker, Marisa, et al.
Publicado: (2018)

TrkA Co-Receptors: The Janus Face of TrkA?
por: Trouvilliez, Sarah, et al.
Publicado: (2023)

Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia
por: Lebedev, Timofey D., et al.
Publicado: (2019)

Transcytosis of TrkA leads to diversification of dendritic signaling endosomes
por: Barford, Kelly, et al.
Publicado: (2018)

Heterogeneous nuclear ribonucleoprotein K is overexpressed in acute myeloid leukemia and causes myeloproliferation in mice via altered Runx1 splicing
por: Aitken, Marisa J L, et al.
Publicado: (2022)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
por: Ye, Mengchen, et al.
Publicado: (2018)

Enhanced TrkA signaling impairs basal forebrain-dependent behavior
por: Calvo-Enrique, Laura, et al.
Publicado: (2023)

Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia
por: Kuang, Shao-Qing, et al.
Publicado: (2013)

The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling
por: Trinh, Bon Q., et al.
Publicado: (2015)

Systems Pharmacology of the NGF Signaling Through p75 and TrkA Receptors
por: Toni, T, et al.
Publicado: (2014)

Activation of the NGF/TrkA signaling pathway attenuates diabetic erectile dysfunction
por: Hou, Yi, et al.
Publicado: (2017)

NGF – the TrkA to successful pain treatment
por: Kumar, Vinayak, et al.
Publicado: (2012)

The Challenge of Targeting Notch in Hematologic Malignancies
por: Hernandez Tejada, Fiorela N., et al.
Publicado: (2014)

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
por: Wong, Hoi Leong Xavier, et al.
Publicado: (2019)

PB1888: TRIAL IN PROGRESS: PHASE 1B/2 STUDY OF PIVEKIMAB SUNIRINE (PVEK, IMGN632) IN COMBINATION WITH VENETOCLAX/AZACITIDINE OR MAGROLIMAB FOR PATIENTS WITH CD123-POSITIVE ACUTE MYELOID LEUKEMIA (AML)
por: Daver, Naval, et al.
Publicado: (2023)

Characterization of KRC-108 as a TrkA Kinase Inhibitor with Anti-Tumor Effects
por: Lee, Hyo Jeong, et al.
Publicado: (2022)

Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes
por: Shao, Yufang, et al.
Publicado: (2002)

The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19
por: Usai, Carla, et al.
Publicado: (2022)

Sprouty4 Is an Endogenous Negative Modulator of TrkA Signaling and Neuronal Differentiation Induced by NGF
por: Alsina, Fernando C., et al.
Publicado: (2012)

Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity
por: Kumar, Vivek, et al.
Publicado: (2015)

The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
por: Canu, Nadia, et al.
Publicado: (2017)

TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
por: Yanpallewar, Sudhirkumar, et al.
Publicado: (2022)

Characterization of NGF, trkA(NGFR), and p75(NTR) in Retina of Mice Lacking Reelin Glycoprotein
por: Balzamino, Bijorn Omar, et al.
Publicado: (2014)

Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
por: Knoechel, Birgit, et al.
Publicado: (2015)

NGF-trkA signaling modulates the analgesic effects of prostatic acid phosphatase in resiniferatoxin-induced neuropathy
por: Wu, Chieh-Hsin, et al.
Publicado: (2016)

Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA
por: Pena, Darlene A., et al.
Publicado: (2018)

Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
por: Zhao, Shu, et al.
Publicado: (2020)

MicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemia
por: Chakraborty, Chiranjib, et al.
Publicado: (2016)

NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma
por: Lee, Seungyong, et al.
Publicado: (2021)

Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity
por: Rogdakis, Thanasis, et al.
Publicado: (2022)

NGF-stimulated retrograde transport of trkA in the mammalian nervous system
Publicado: (1995)

NGF Causes TrkA to Specifically Attract Microtubules to Lipid Rafts
por: Pryor, Shona, et al.
Publicado: (2012)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria
por: Feinberg, Konstantin, et al.
Publicado: (2017)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
por: Mason, Ashley J., et al.
Publicado: (2023)

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons
por: Latina, Valentina, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_id5oqluvh46e01alrtn21prkie