Cargando…
IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence
The role of IL-27 in antiviral immunity is still incompletely understood, especially in the context of chronic viruses that induce a unique environment in their infected host. Cytomegalovirus (CMV) establishes a persistent, tissue localized infection followed by lifelong latency. CMV infects the maj...
Autores principales: | Wehrens, Ellen J., Wong, Kurt A., Gupta, Ankan, Khan, Ayesha, Benedict, Chris A., Zuniga, Elina I. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059457/ https://www.ncbi.nlm.nih.gov/pubmed/30044874 http://dx.doi.org/10.1371/journal.pone.0201249 |
Ejemplares similares
-
Interleukin-27R Signaling Mediates Early Viral Containment and Impacts Innate and Adaptive Immunity after Chronic Lymphocytic Choriomeningitis Virus Infection
por: Harker, James A., et al.
Publicado: (2018) -
Cytomegalovirus-Specific IL-10-Producing CD4(+) T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence
por: Clement, Mathew, et al.
Publicado: (2016) -
IL-6 and IL-27 play both distinct and redundant roles in regulating CD4 T-cell responses during chronic viral infection
por: Harker, James A., et al.
Publicado: (2023) -
Impact of IL-27 on hepatocyte antiviral gene expression and function
por: Ramamurthy, Narayan, et al.
Publicado: (2016) -
Cytomegalovirus exploits IL-10–mediated immune regulation in the salivary glands
por: Humphreys, Ian R., et al.
Publicado: (2007)