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α-synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum-Golgi compartment

Although previous work has demonstrated that the overexpression of wild-type or mutant α-synuclein (α-syn) can induce cell death via a number of different mechanisms, including oxidative stress, dysfunction of the ubiquitin-proteasome degradation system, mitochondrial damage and endoplasmic reticulu...

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Detalles Bibliográficos
Autores principales: Liu, Mei, Qin, Lixia, Wang, Lili, Tan, Jieqiong, Zhang, Hainan, Tang, Jianguang, Shen, Xiangmin, Tan, Liming, Wang, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059687/
https://www.ncbi.nlm.nih.gov/pubmed/29749529
http://dx.doi.org/10.3892/mmr.2018.9002