Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa

Detection of bacterial ligands is a pre-requisite for inflammasome activation. During Pseudomonas aeruginosa infection, flagellin which is secreted through the T3SS is detected by the NLRC4 inflammasome. Activation of the NLRC4 inflammasome is believed to contribute to high IL-1β production and path...

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Detalles Bibliográficos
Autores principales: Balakrishnan, Arjun, Karki, Rajendra, Berwin, Brent, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060091/
https://www.ncbi.nlm.nih.gov/pubmed/30062052
http://dx.doi.org/10.1038/s41420-018-0068-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060091/
https://www.ncbi.nlm.nih.gov/pubmed/30062052
http://dx.doi.org/10.1038/s41420-018-0068-z

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