Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks

Genetic variants can confer risk to complex genetic diseases by modulating gene expression through changes to the epigenome. To assess the degree to which genetic variants influence epigenome activity, we integrate epigenetic and genotypic data from lupus patient lymphoblastoid cell lines to identif...

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Detalles Bibliográficos
Autores principales: Pelikan, Richard C., Kelly, Jennifer A., Fu, Yao, Lareau, Caleb A., Tessneer, Kandice L., Wiley, Graham B., Wiley, Mandi M., Glenn, Stuart B., Harley, John B., Guthridge, Joel M., James, Judith A., Aryee, Martin J., Montgomery, Courtney, Gaffney, Patrick M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060153/
https://www.ncbi.nlm.nih.gov/pubmed/30046115
http://dx.doi.org/10.1038/s41467-018-05328-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060153/
https://www.ncbi.nlm.nih.gov/pubmed/30046115
http://dx.doi.org/10.1038/s41467-018-05328-9

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