Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling

The ankyrin 3 gene (ANK3) is a well-established risk gene for psychiatric illness, but the mechanisms underlying its pathophysiology remain elusive. We examined the molecular effects of disrupting brain-specific Ank3 isoforms in mouse and neuronal model systems. RNA sequencing of hippocampus from An...

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Detalles Bibliográficos
Autores principales: Garza, Jacob C., Qi, Xiaoli, Gjeluci, Klaudio, Leussis, Melanie P., Basu, Himanish, Reis, Surya A., Zhao, Wen Ning, Piguel, Nicolas H., Penzes, Peter, Haggarty, Stephen J., Martens, Gerard J., Poelmans, Geert, Petryshen, Tracey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060177/
https://www.ncbi.nlm.nih.gov/pubmed/30046097
http://dx.doi.org/10.1038/s41398-018-0182-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060177/
https://www.ncbi.nlm.nih.gov/pubmed/30046097
http://dx.doi.org/10.1038/s41398-018-0182-y

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