Cargando…

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

Eukaryotic initiation factor 5A (eIF5A) is a conserved protein with an essential role in translation elongation. Using one and two-dimensional western blotting, we showed that the eIF5A protein level was 2-fold lower in benznidazole (BZ)-resistant (BZR and 17LER) Trypanosoma cruzi populations than i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moreira, Douglas de Souza, Duarte, Ana Paula, Pais, Fabiano Sviatopolk Mirsky, da Silva-Pereira, Rosiane Aparecida, Romanha, Alvaro José, Schenkman, Sergio, Murta, Silvane Maria Fonseca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060400/ https://www.ncbi.nlm.nih.gov/pubmed/30066751 http://dx.doi.org/10.1590/0074-02760180162

Ejemplares similares

Molecular characterization of the hexose transporter gene in benznidazole resistant and susceptible populations of Trypanosoma cruzi
por: dos Santos, Paula F, et al.
Publicado: (2012)

Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations
por: Lima, Davi Alvarenga, et al.
Publicado: (2023)

Drug transporter and oxidative stress gene expression in human macrophages infected with benznidazole-sensitive and naturally benznidazole-resistant Trypanosoma cruzi parasites treated with benznidazole
por: Téllez, Jair, et al.
Publicado: (2019)

In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures
por: Lavorato, Stefânia Neiva, et al.
Publicado: (2015)

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics
por: Trochine, Andrea, et al.
Publicado: (2014)

Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo
por: Batista, Denise da Gama Jaén, et al.
Publicado: (2011)

Nanocarrier-enhanced intracellular delivery of benznidazole for treatment of Trypanosoma cruzi infection
por: Li, Xiaomo, et al.
Publicado: (2021)

Benznidazole Treatment: Time- and Dose-Dependence Varies with the Trypanosoma cruzi Strain
por: Fonseca, Kátia da Silva, et al.
Publicado: (2021)

Benznidazole-resistance in Trypanosoma cruzi: Evidence that distinct mechanisms can act in concert()
por: Campos, Mônica C.O., et al.
Publicado: (2014)

Miltefosine and Benznidazole Combination Improve Anti-Trypanosoma cruzi In Vitro and In Vivo Efficacy
por: Gulin, Julián Ernesto Nicolás, et al.
Publicado: (2022)

Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice
por: Gonzaga, Beatriz Matheus Souza, et al.
Publicado: (2022)

Protein Synthesis Attenuation by Phosphorylation of eIF2α Is Required for the Differentiation of Trypanosoma cruzi into Infective Forms
por: Tonelli, Renata R., et al.
Publicado: (2011)

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole
por: Zingales, Bianca, et al.
Publicado: (2015)

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment
por: Aguilera, Elena, et al.
Publicado: (2018)

Anti-parasitic effect of vitamin C alone and in combination with benznidazole against Trypanosoma cruzi
por: Puente, Vanesa, et al.
Publicado: (2018)

Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease
por: Assíria Fontes Martins, Tassiane, et al.
Publicado: (2015)

Benznidazole and amiodarone combined treatment attenuates cytoskeletal damage in Trypanosoma cruzi-infected cardiac cells
por: Barbosa, Juliana Magalhães Chaves, et al.
Publicado: (2022)

Antiparasitic Activity of Hippeastrum Species and Synergistic Interaction between Montanine and Benznidazole against Trypanosoma cruzi
por: Piñeiro, Mauricio, et al.
Publicado: (2023)

A Quinoxaline Derivative as a Potent Chemotherapeutic Agent, Alone or in Combination with Benznidazole, against Trypanosoma cruzi
por: Rodrigues, Jean Henrique da Silva, et al.
Publicado: (2014)

Identification of inhibitors for the transmembrane Trypanosoma cruzi eIF2α kinase relevant for parasite proliferation
por: Marcelino, Tiago de Paula, et al.
Publicado: (2023)

Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population
por: Mejia, Ana Maria, et al.
Publicado: (2012)

Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study
por: Colantonio, Lisandro D., et al.
Publicado: (2016)

Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice
por: Diniz, Lívia de Figueiredo, et al.
Publicado: (2018)

Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole
por: García-Huertas, Paola, et al.
Publicado: (2017)

Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole
por: Calvet, Claudia Magalhães, et al.
Publicado: (2020)

In vitro susceptibility of Trypanosoma cruzi discrete typing units (DTUs) to benznidazole: A systematic review and meta-analysis
por: Vela, Andrea, et al.
Publicado: (2021)

Experimental Combination Therapy with Amiodarone and Low-Dose Benznidazole in a Mouse Model of Trypanosoma cruzi Acute Infection
por: Barbosa, Juliana Magalhães Chaves, et al.
Publicado: (2022)

Sensibilidad in vitro a benznidazol, nifurtimox y posaconazol de cepas de Trypanosoma cruzi de Paraguay
por: Acosta, Nidia, et al.
Publicado: (2020)

Anti-Trypanosoma cruzi antibody profiling in patients with Chagas disease treated with benznidazole assessed by genome phage display
por: Rodriguez Carnero, Luis Antonio, et al.
Publicado: (2023)

Oral Exposure to Phytomonas serpens Attenuates Thrombocytopenia and Leukopenia during Acute Infection with Trypanosoma cruzi
por: da Silva, Rosiane V., et al.
Publicado: (2013)

Benznidazole Therapy Modulates Interferon-γ and M2 Muscarinic Receptor Autoantibody Responses in Trypanosoma cruzi-Infected Children
por: Cutrullis, Romina A., et al.
Publicado: (2011)

Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection
por: Gatto, Mariana, et al.
Publicado: (2017)

The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi
por: Horta, Aline Luciano, et al.
Publicado: (2018)

Frequency variation and dose modification of benznidazole administration for the treatment of Trypanosoma cruzi infection in mice, dogs and non-human primates
por: Bustamante, Juan M., et al.
Publicado: (2023)

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice
por: Jayawardhana, Shiromani, et al.
Publicado: (2023)

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi
por: da Silva Augusto, Leonardo, et al.
Publicado: (2015)

Benznidazole treatment decreases IL-6 levels in Trypanosoma cruzi-infected human adipocytes differentiated from adipose tissue-derived stem cells
por: Moreira, Leyllane Rafael, et al.
Publicado: (2023)

Differential Expression Profiles in the Midgut of Triatoma infestans Infected with Trypanosoma cruzi
por: Buarque, Diego S., et al.
Publicado: (2013)

Crystal structure of the Trypanosoma cruzi EIF4E5 translation factor homologue in complex with mRNA cap-4
por: Reolon, Lidia Watanabe, et al.
Publicado: (2019)

Trypanosoma cruzi iron superoxide dismutases: insights from phylogenetics to chemotherapeutic target assessment
por: Hickson, Jéssica, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4qtrs59p13t0da5se570rvov2h