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Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors

BACKGROUND: Small intestinal neuroendocrine tumors (SI-NETs) originate from enterochromaffin cells scattered in the intestinal mucosa of the ileum and jejunum. Loss of one copy of chromosome 18 is the most frequent observed aberration in primary tumors and metastases. The aim of this study was to in...

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Detalles Bibliográficos
Autores principales: Barazeghi, Elham, Prabhawa, Surendra, Norlén, Olov, Hellman, Per, Stålberg, Peter, Westin, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060499/
https://www.ncbi.nlm.nih.gov/pubmed/30045709
http://dx.doi.org/10.1186/s12885-018-4579-z