Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

Drug–target binding kinetics (as determined by association and dissociation rate constants, k(on) and k(off)) can be an important determinant of the kinetics of drug action. However, the effect compartment model is used most frequently instead of a target binding model to describe hysteresis. Here w...

Descripción completa

Detalles Bibliográficos
Autores principales: de Witte, Wilhelmus E. A., Rottschäfer, Vivi, Danhof, Meindert, van der Graaf, Piet H., Peletier, Lambertus A., de Lange, Elizabeth C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061075/
https://www.ncbi.nlm.nih.gov/pubmed/29777407
http://dx.doi.org/10.1007/s10928-018-9593-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061075/
https://www.ncbi.nlm.nih.gov/pubmed/29777407
http://dx.doi.org/10.1007/s10928-018-9593-x

Ejemplares similares