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Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models
Drug–target binding kinetics (as determined by association and dissociation rate constants, k(on) and k(off)) can be an important determinant of the kinetics of drug action. However, the effect compartment model is used most frequently instead of a target binding model to describe hysteresis. Here w...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061075/ https://www.ncbi.nlm.nih.gov/pubmed/29777407 http://dx.doi.org/10.1007/s10928-018-9593-x |