Model reduction in mathematical pharmacology: Integration, reduction and linking of PBPK and systems biology models

In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales. To address the issue of model complexity, we propose the reduction of each t...

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Detalles Bibliográficos
Autores principales: Snowden, Thomas J., van der Graaf, Piet H., Tindall, Marcus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061126/
https://www.ncbi.nlm.nih.gov/pubmed/29582349
http://dx.doi.org/10.1007/s10928-018-9584-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061126/
https://www.ncbi.nlm.nih.gov/pubmed/29582349
http://dx.doi.org/10.1007/s10928-018-9584-y

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