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Model reduction in mathematical pharmacology: Integration, reduction and linking of PBPK and systems biology models
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration across multiple scales. To address the issue of model complexity, we propose the reduction of each t...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061126/ https://www.ncbi.nlm.nih.gov/pubmed/29582349 http://dx.doi.org/10.1007/s10928-018-9584-y |