Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

Molecular changes induced by excessive alcohol consumption may underlie formation of dysphoric state during acute and protracted alcohol withdrawal which leads to craving and relapse. A main molecular addiction hypothesis is that the upregulation of the dynorphin (DYN)/κ-opioid receptor (KOR) system...

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Detalles Bibliográficos
Autores principales: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Yakovleva, Tatiana, Hansson, Anita C., Sommer, Wolfgang H., Spanagel, Rainer, Bakalkin, Georgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061161/
https://www.ncbi.nlm.nih.gov/pubmed/29383684
http://dx.doi.org/10.1007/s12035-017-0844-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061161/
https://www.ncbi.nlm.nih.gov/pubmed/29383684
http://dx.doi.org/10.1007/s12035-017-0844-4

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