High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves

KEY MESSAGE: The potent anti-HIV microbicide griffithsin was expressed to high levels in tobacco chloroplasts, enabling efficient purification from both fresh and dried biomass, thus providing storable material for inexpensive production and scale-up on demand. ABSTRACT: The global HIV epidemic cont...

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Detalles Bibliográficos
Autores principales: Hoelscher, Matthijs, Tiller, Nadine, Teh, Audrey Y.-H., Wu, Guo-Zhang, Ma, Julian K-C., Bock, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061503/
https://www.ncbi.nlm.nih.gov/pubmed/29948657
http://dx.doi.org/10.1007/s11103-018-0744-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061503/
https://www.ncbi.nlm.nih.gov/pubmed/29948657
http://dx.doi.org/10.1007/s11103-018-0744-7

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