Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast

The interaction of the eukaryotic initiation factor 4G (eIF4G) with the cap-binding protein eIF4E initiates cap-dependent translation and is regulated by the 4E-binding proteins (4E-BPs), which compete with eIF4G to repress translation. Metazoan eIF4G and 4E-BPs interact with eIF4E via canonical and...

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Detalles Bibliográficos
Autores principales: Grüner, Stefan, Weber, Ramona, Peter, Daniel, Chung, Min-Yi, Igreja, Cátia, Valkov, Eugene, Izaurralde, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061780/
https://www.ncbi.nlm.nih.gov/pubmed/30053226
http://dx.doi.org/10.1093/nar/gky542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061780/
https://www.ncbi.nlm.nih.gov/pubmed/30053226
http://dx.doi.org/10.1093/nar/gky542

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