High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing

DNA polymerase fidelity is affected by both intrinsic properties and environmental conditions. Current strategies for measuring DNA polymerase error rate in vitro are constrained by low error subtype sensitivity, poor scalability, and lack of flexibility in types of sequence contexts that can be tes...

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Detalles Bibliográficos
Autores principales: de Paz, Alexandra M, Cybulski, Thaddeus R, Marblestone, Adam H, Zamft, Bradley M, Church, George M, Boyden, Edward S, Kording, Konrad P, Tyo, Keith E J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061839/
https://www.ncbi.nlm.nih.gov/pubmed/29718339
http://dx.doi.org/10.1093/nar/gky296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061839/
https://www.ncbi.nlm.nih.gov/pubmed/29718339
http://dx.doi.org/10.1093/nar/gky296

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