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Bile diversion, a bariatric surgery, and bile acid signaling reduce central cocaine reward

The gut-to-brain axis exhibits significant control over motivated behavior. However, mechanisms supporting this communication are poorly understood. We reveal that a gut-based bariatric surgery chronically elevates systemic bile acids and attenuates cocaine-induced elevations in accumbal dopamine. N...

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Detalles Bibliográficos
Autores principales: Reddy, India A., Smith, Nicholas K., Erreger, Kevin, Ghose, Dipanwita, Saunders, Christine, Foster, Daniel J., Turner, Brandon, Poe, Amanda, Albaugh, Vance L., McGuinness, Owen, Hackett, Troy A., Grueter, Brad A., Abumrad, Naji N., Flynn, Charles Robb, Galli, Aurelio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061973/
https://www.ncbi.nlm.nih.gov/pubmed/30048457
http://dx.doi.org/10.1371/journal.pbio.2006682