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Testing an optimally weighted combination of common and/or rare variants with multiple traits

Recently, joint analysis of multiple traits has become popular because it can increase statistical power to identify genetic variants associated with complex diseases. In addition, there is increasing evidence indicating that pleiotropy is a widespread phenomenon in complex diseases. Currently, most...

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Detalles Bibliográficos
Autores principales: Wang, Zhenchuan, Sha, Qiuying, Fang, Shurong, Zhang, Kui, Zhang, Shuanglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062080/
https://www.ncbi.nlm.nih.gov/pubmed/30048520
http://dx.doi.org/10.1371/journal.pone.0201186