A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability

Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If uncontrolled, hyperpermeability leads to an impaired barrier, fluid leakage and edema, which can contribute to multi-organ failure and death....

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Detalles Bibliográficos
Autores principales: Amado-Azevedo, Joana, de Menezes, Renee X., van Nieuw Amerongen, Geerten P., van Hinsbergh, Victor W. M., Hordijk, Peter L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062096/
https://www.ncbi.nlm.nih.gov/pubmed/30048510
http://dx.doi.org/10.1371/journal.pone.0201231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062096/
https://www.ncbi.nlm.nih.gov/pubmed/30048510
http://dx.doi.org/10.1371/journal.pone.0201231

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