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A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability
Thrombin and other inflammatory mediators may induce vascular permeability through the disruption of adherens junctions between adjacent endothelial cells. If uncontrolled, hyperpermeability leads to an impaired barrier, fluid leakage and edema, which can contribute to multi-organ failure and death....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062096/ https://www.ncbi.nlm.nih.gov/pubmed/30048510 http://dx.doi.org/10.1371/journal.pone.0201231 |