Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Niemann-Pick C1 (NPC1) is a polytopic membrane protein with 13 transmembrane helices that exports LDL-derived cholesterol from lysosomes by carrying it through the 80 Å glycocalyx and the 40 Å lipid bilayer. Transport begins when cholesterol binds to the N-terminal domain (NTD) of NPC1, which projec...

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Detalles Bibliográficos
Autores principales: Trinh, Michael Nguyen, Brown, Michael S, Seemann, Joachim, Goldstein, Joseph L, Lu, Feiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062155/
https://www.ncbi.nlm.nih.gov/pubmed/30047864
http://dx.doi.org/10.7554/eLife.38564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062155/
https://www.ncbi.nlm.nih.gov/pubmed/30047864
http://dx.doi.org/10.7554/eLife.38564

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