Cargando…

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1

Niemann-Pick C1 (NPC1) is a polytopic membrane protein with 13 transmembrane helices that exports LDL-derived cholesterol from lysosomes by carrying it through the 80 Å glycocalyx and the 40 Å lipid bilayer. Transport begins when cholesterol binds to the N-terminal domain (NTD) of NPC1, which projec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trinh, Michael Nguyen, Brown, Michael S, Seemann, Joachim, Goldstein, Joseph L, Lu, Feiran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062155/ https://www.ncbi.nlm.nih.gov/pubmed/30047864 http://dx.doi.org/10.7554/eLife.38564

Ejemplares similares

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
por: Lu, Feiran, et al.
Publicado: (2015)

Lysosomal membrane glycoproteins bind cholesterol and contribute to lysosomal cholesterol export
por: Li, Jian, et al.
Publicado: (2016)

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine
por: Trinh, Michael N., et al.
Publicado: (2020)

Biochemical reconstitution of branching microtubule nucleation
por: Alfaro-Aco, Raymundo, et al.
Publicado: (2020)

Lysosomal and Mitochondrial Liaisons in Niemann-Pick Disease
por: Torres, Sandra, et al.
Publicado: (2017)

Reconstitution reveals two paths of force transmission through the kinetochore
por: Hamilton, Grace E, et al.
Publicado: (2020)

Activation Mobilizes the Cholesterol in the Late Endosomes-Lysosomes of Niemann Pick Type C Cells
por: Lange, Yvonne, et al.
Publicado: (2012)

Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol
por: Trinh, Michael N., et al.
Publicado: (2022)

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function
por: Gerndt, Susanne, et al.
Publicado: (2020)

New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins
por: Angiulli, Gabriella, et al.
Publicado: (2020)

Functional reconstitution of a bacterial CO(2) concentrating mechanism in Escherichia coli
por: Flamholz, Avi I, et al.
Publicado: (2020)

Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins
por: Hernández-Rocamora, Víctor M, et al.
Publicado: (2021)

In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters
por: Setyawati, Inda, et al.
Publicado: (2020)

In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases
por: Sutherland, Molly C, et al.
Publicado: (2021)

YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs
por: Roundtree, Ian A, et al.
Publicado: (2017)

Niemann-Pick Disease: An Underdiagnosed Lysosomal Storage Disorder
por: Panigrahi, Inusha, et al.
Publicado: (2019)

Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80
por: Kern, David M, et al.
Publicado: (2017)

Lysosomal-specific Cholesterol Reduction by Biocleavable Polyrotaxanes for Ameliorating Niemann-Pick Type C Disease
por: Tamura, Atsushi, et al.
Publicado: (2014)

Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals
por: Li, Yuling, et al.
Publicado: (2019)

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
por: Manthei, Kelly A, et al.
Publicado: (2018)

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase
por: Coates, Hudson W, et al.
Publicado: (2023)

Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles
por: Le, Henry H, et al.
Publicado: (2020)

Visualization of cholesterol deposits in lysosomes of Niemann-Pick type C fibroblasts using recombinant perfringolysin O
por: Kwiatkowska, Katarzyna, et al.
Publicado: (2014)

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
por: Eapen, Vinay V, et al.
Publicado: (2021)

The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP
por: Massa López, David, et al.
Publicado: (2019)

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
por: Startek, Justyna B, et al.
Publicado: (2019)

Intracellular cholesterol trafficking is dependent upon NPC2 interaction with lysobisphosphatidic acid
por: McCauliff, Leslie A, et al.
Publicado: (2019)

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis
por: Das, Akash, et al.
Publicado: (2014)

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex
por: Naito, Tomoki, et al.
Publicado: (2019)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
por: Hu, Xuchen, et al.
Publicado: (2019)

Inter-domain dynamics drive cholesterol transport by NPC1 and NPC1L1 proteins
por: Saha, Piyali, et al.
Publicado: (2020)

PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder
por: Brown, Anna, et al.
Publicado: (2016)

Juvenile CLN3 disease is a lysosomal cholesterol storage disorder: similarities with Niemann-Pick type C disease
por: Chen, Jacinda, et al.
Publicado: (2023)

c-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease
por: Marín, Tamara, et al.
Publicado: (2022)

Mitochondrial Cholesterol in Alzheimer's Disease and Niemann–Pick Type C Disease
por: Torres, Sandra, et al.
Publicado: (2019)

Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway
por: Chim, Nicholas, et al.
Publicado: (2018)

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C
por: Lim, Chun-Yan, et al.
Publicado: (2019)

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
por: Carette, Jan E., et al.
Publicado: (2011)

Homo-oligomerization of the human adenosine A(2A) receptor is driven by the intrinsically disordered C-terminus
por: Nguyen, Khanh Dinh Quoc, et al.
Publicado: (2021)

Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
por: Juette, Manuel F, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cejevnvgl1k67p1khpiurm4nc3