Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data

Prediction of compound toxicity is essential because covering the vast chemical space requiring safety assessment using traditional experimentally-based, resource-intensive techniques is impossible. However, such prediction is nontrivial due to the complex causal relationship between compound struct...

Descripción completa

Detalles Bibliográficos
Autores principales: Allen, Chad H. G., Koutsoukas, Alexios, Cortés-Ciriano, Isidro, Murrell, Daniel S., Malliavin, Thérèse E., Glen, Robert C., Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062365/
https://www.ncbi.nlm.nih.gov/pubmed/30090397
http://dx.doi.org/10.1039/c5tx00406c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062365/
https://www.ncbi.nlm.nih.gov/pubmed/30090397
http://dx.doi.org/10.1039/c5tx00406c

Ejemplares similares