Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors

Attempts to exploit the cytotoxic activity of death receptors (DR) for treating cancer have thus far been disappointing. DR activation in most malignant cells fails to trigger cell death and may even promote tumor growth by activating cell death-independent DR-associated signaling pathways. Overcomi...

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Detalles Bibliográficos
Autores principales: Sirtl, Simon, Knoll, Gertrud, Trinh, Dieu Thuy, Lang, Isabell, Siegmund, Daniela, Gross, Stefanie, Schuler-Thurner, Beatrice, Neubert, Patrick, Jantsch, Jonathan, Wajant, Harald, Ehrenschwender, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062497/
https://www.ncbi.nlm.nih.gov/pubmed/29706657
http://dx.doi.org/10.1038/s41388-018-0265-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062497/
https://www.ncbi.nlm.nih.gov/pubmed/29706657
http://dx.doi.org/10.1038/s41388-018-0265-5

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