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Hypertonicity-enforced BCL-2 addiction unleashes the cytotoxic potential of death receptors
Attempts to exploit the cytotoxic activity of death receptors (DR) for treating cancer have thus far been disappointing. DR activation in most malignant cells fails to trigger cell death and may even promote tumor growth by activating cell death-independent DR-associated signaling pathways. Overcomi...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062497/ https://www.ncbi.nlm.nih.gov/pubmed/29706657 http://dx.doi.org/10.1038/s41388-018-0265-5 |