Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells

Anticancer activities of flavonoids derived from Tephroseris kirilowii (Turcz.) Holub. were evaluated in human cancer cells. We isolated and identified, for the first time, eight flavonoids from T. kirilowii and found that three of them (IH: isorhamnetin, GN: genkwanin, and Aca: acacetin) inhibited...

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Detalles Bibliográficos
Autores principales: Zhang, Hong-Wei, Hu, Jin-Jiao, Fu, Ruo-Qiu, Liu, Xin, Zhang, Yan-Hao, Li, Jing, Liu, Lei, Li, Yu-Nong, Deng, Qin, Luo, Qing-Song, Ouyang, Qin, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062549/
https://www.ncbi.nlm.nih.gov/pubmed/30050147
http://dx.doi.org/10.1038/s41598-018-29308-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062549/
https://www.ncbi.nlm.nih.gov/pubmed/30050147
http://dx.doi.org/10.1038/s41598-018-29308-7

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