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PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart
Cardiac hypertrophy occurs in response to increased hemodynamic demand and can progress to heart failure. Identifying the key regulators of this process is clinically important. Though it is thought that the phosphorylation of histone deacetylase (HDAC) 2 plays a crucial role in the development of p...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062565/ https://www.ncbi.nlm.nih.gov/pubmed/30050113 http://dx.doi.org/10.1038/s12276-018-0121-2 |