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Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation

The endosomal sorting complex required for transport (ESCRT) machinery mediates cargo sorting, membrane deformation and membrane scission on the surface of endosomes, generating intraluminal vesicles (ILVs) to degrade signaling receptors. By live-cell imaging of individual endosomes in human cells,...

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Detalles Bibliográficos
Autores principales: Wenzel, Eva Maria, Schultz, Sebastian Wolfgang, Schink, Kay Oliver, Pedersen, Nina Marie, Nähse, Viola, Carlson, Andreas, Brech, Andreas, Stenmark, Harald, Raiborg, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062606/
https://www.ncbi.nlm.nih.gov/pubmed/30050131
http://dx.doi.org/10.1038/s41467-018-05345-8