Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways

Mutations in Vaccinia-related kinase 1 (VRK1) have emerged as a cause of severe neuronal phenotypes in human, including brain developmental defects and degeneration of spinal motor neurons, leading to Spinal Muscular Atrophy (SMA) or early onset Amyotrophic Lateral Sclerosis (ALS). Vrk1 gene-trap pa...

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Detalles Bibliográficos
Autores principales: Vinograd-Byk, Hadar, Renbaum, Paul, Levy-Lahad, Ephrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062608/
https://www.ncbi.nlm.nih.gov/pubmed/30050127
http://dx.doi.org/10.1038/s41598-018-29215-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062608/
https://www.ncbi.nlm.nih.gov/pubmed/30050127
http://dx.doi.org/10.1038/s41598-018-29215-x

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