Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception

[Image: see text] Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biology, mass spectrometry, and cell-ba...

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Detalles Bibliográficos
Autores principales: Pellock, Samuel J., Creekmore, Benjamin C., Walton, William G., Mehta, Naimee, Biernat, Kristen A., Cesmat, Andrew P., Ariyarathna, Yamuna, Dunn, Zachary D., Li, Bo, Jin, Jian, James, Lindsey I., Redinbo, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062831/
https://www.ncbi.nlm.nih.gov/pubmed/30062115
http://dx.doi.org/10.1021/acscentsci.8b00239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062831/
https://www.ncbi.nlm.nih.gov/pubmed/30062115
http://dx.doi.org/10.1021/acscentsci.8b00239

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