ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms

Expression of human Apolipoprotein E (APOE) modulates the inflammatory response in an isoform specific manner, with APOE4 isoform eliciting a stronger pro-inflammatory response, suggesting a possible mechanism for worse outcome following traumatic brain injury (TBI). APOE lipidation and stability is...

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Detalles Bibliográficos
Autores principales: Castranio, Emilie L., Wolfe, Cody M., Nam, Kyong Nyon, Letronne, Florent, Fitz, Nicholas F., Lefterov, Iliya, Koldamova, Radosveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062955/
https://www.ncbi.nlm.nih.gov/pubmed/30049279
http://dx.doi.org/10.1186/s40478-018-0569-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062955/
https://www.ncbi.nlm.nih.gov/pubmed/30049279
http://dx.doi.org/10.1186/s40478-018-0569-2

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