Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA

Neurons are highly vulnerable to DNA damage induced by genotoxic agents such as topoisomerase activity, oxidative stress, ionizing radiation (IR) and chemotherapeutic drugs. To avert the detrimental effects of DNA lesions in genome stability, transcription and apoptosis, neurons activate robust DNA...

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Detalles Bibliográficos
Autores principales: Mata-Garrido, Jorge, Tapia, Olga, Casafont, Iñigo, Berciano, Maria T., Cuadrado, Ana, Lafarga, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062993/
https://www.ncbi.nlm.nih.gov/pubmed/30049290
http://dx.doi.org/10.1186/s40478-018-0573-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062993/
https://www.ncbi.nlm.nih.gov/pubmed/30049290
http://dx.doi.org/10.1186/s40478-018-0573-6

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